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1-What criteria would be appropriate for choosing a model for testing new drugs for prevention of ischaemia-induced ventricular fibrillation? compare the utility of different models and approaches 2- Describe and explain the rationale behind the current pharmacological treatment of pulmonary arterial hypertension, Also, based on what is known about the pathophysiology of this condition, propose two additional mechanisms, not currently exploited, which might be targeted in order to treat it.

The essay is made of 2 different questions, Answer to each question around 1400 words.Do not add a bibliography but if you consider (up to three) investigators to have made a standout contribution you may mention their names in the main text (e.g., aspirin, whose mechanism of action was discovered by Vane and colleagues using the blood-superfused isolated tissue assay cascade).I have attached the related lectures and articles for each question which you can use. Please use these.