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Using complete sentences, in a prose format, describe at least FIVE significant flaws in the design and implementation of this study; and, propose how the investigators could address each of these limitations to improve the quality of this study.

Read the pilot study, “Hydroxychloroquine and azithromycin as a
treatment of COVID-19: results of an open-label non-randomized clinical trial”. Using complete sentences, in a prose format, describe at least FIVE significant flaws in the design and implementation of this study; and, propose how the investigators could address each of these limitations to improve the quality of this study. Also, propose TWO approach that could be used to measure the impact of this experimental treatment on immune responses.